Adaptive Control Strategies for Bioprinting Tissues and Organs in Biomedical Engineering Applications
DOI:
https://doi.org/10.56294/mw2023100Keywords:
Bioprinting Tissues, Biomedical Engineering, Adaptive Control Strategies, Scalable Shuffled Shepherd-tuned adaptive PID controller (SSS-Adaptive PID)Abstract
Bioprinting is a revolutionary technology in the area of producing organs and tissues in biomedical engineering. Despite potential, variability in bioinks, nonlinear dynamics, and variability in the environment cause precision and reliability in the process. The current methods, such as the Proportional-Integral-Derivative (PID) controller, are plagued with disadvantages such as slow convergence, susceptibility to local minima, and a lack of adaptability in variable conditions. Overcoming these disadvantages, a hybrid system is presented, Scalable Shuffled Shepherd-tuned adaptive PID controller (SSS-Adaptive PID). The Adaptive PID Controller dynamically adapts in real time with variable conditions and guarantees stability and responsiveness. The SSS Optimization maximizes optimization with increased convergence and enhanced robustness and overcomes the issues with time-varying and nonlinear conditions in bioprinting. The results of the experiments are reduced Rise Time (0.21 × 10⁻5 sec), Settling Time (0.05 × 10⁻3 sec) and peak time (0.09 × 10⁻3 sec). Improved cell viability and structure fidelity are also noted in printed constructs. It overcomes the disadvantages to conventional methods and is a consistent and efficient solution in 3D bioprinting. By permitting adaptive and accurate control, the system makes high-quality organs and tissues production possible in biomedical applications.
References
1. Aljohani W, Ullah MW, Zhang X, Yang G. Bioprinting and its applications in tissue engineering and regenerative medicine. International journal of biological macromolecules. 2018 Feb 1;107:261-75. https://doi.org/10.1016/j.ijbiomac.2017.08.171 DOI: https://doi.org/10.1016/j.ijbiomac.2017.08.171
2. Mota C, Camarero-Espinosa S, Baker MB, Wieringa P, Moroni L. Bioprinting: from tissue and organ development to in vitro models. Chemical reviews. 2020 May 14;120(19):10547-607. https://doi.org/10.1021/acs.chemrev.9b00789 DOI: https://doi.org/10.1021/acs.chemrev.9b00789
3. Xie Z, Gao M, Lobo AO, Webster TJ. 3D bioprinting in tissue engineering for medical applications: the classic and the hybrid. Polymers. 2020 Jul 31;12(8):1717. https://doi.org/10.3390/polym12081717 DOI: https://doi.org/10.3390/polym12081717
4. Ghidini T. Regenerative medicine and 3D bioprinting for human space exploration and planet colonisation. Journal of thoracic disease. 2018 Jul;10(Suppl 20):S2363. 10.21037/jtd.2018.03.19 DOI: https://doi.org/10.21037/jtd.2018.03.19
5. Kim BS, Das S, Jang J, Cho DW. Decellularized extracellular matrix-based bioinks for engineering tissue-and organ-specific microenvironments. Chemical reviews. 2020 Jul 31;120(19):10608-61. https://doi.org/10.1021/acs.chemrev.9b00808 DOI: https://doi.org/10.1021/acs.chemrev.9b00808
6. Aboelhassan A, Abdelgeliel M, Zakzouk EE, Galea M. Design and Implementation of model predictive control based PID controller for industrial applications. Energies. 2020 Dec 14;13(24):6594. https://doi.org/10.3390/en13246594 DOI: https://doi.org/10.3390/en13246594
7. Heinrich MA, Liu W, Jimenez A, Yang J, Akpek A, Liu X, Pi Q, Mu X, Hu N, Schiffelers RM, Prakash J. 3D bioprinting: from benches to translational applications. Small. 2019 Jun;15(23):1805510. https://doi.org/10.1002/smll.201805510 DOI: https://doi.org/10.1002/smll.201805510
8. Ng WL, Chan A, Ong YS, Chua CK. Deep learning for fabrication and maturation of 3D bioprinted tissues and organs. Virtual and Physical Prototyping. 2020 Jul 2;15(3):340-58. https://doi.org/10.1080/17452759.2020.1771741 DOI: https://doi.org/10.1080/17452759.2020.1771741
9. Gao Q, Kim BS, Gao G. Advanced strategies for 3D bioprinting of tissue and organ analogs using alginate hydrogel bioinks. Marine Drugs. 2021 Dec 15;19(12):708. https://doi.org/10.3390/md19120708 DOI: https://doi.org/10.3390/md19120708
10. Tamay DG, Dursun Usal T, Alagoz AS, Yucel D, Hasirci N, Hasirci V. 3D and 4D printing of polymers for tissue engineering applications. Frontiers in bioengineering and biotechnology. 2019 Jul 9;7:164. https://doi.org/10.3389/fbioe.2019.00164 DOI: https://doi.org/10.3389/fbioe.2019.00164
11. Yong U, Lee S, Jung S, Jang J. Interdisciplinary approaches to advanced cardiovascular tissue engineering: ECM-based biomaterials, 3D bioprinting, and its assessment. Progress in Biomedical Engineering. 2020 Sep 18;2(4):042003. DOI 10.1088/2516-1091/abb211 DOI: https://doi.org/10.1088/2516-1091/abb211
12. Wu Y, Ravnic DJ, Ozbolat IT. Intraoperative bioprinting: repairing tissues and organs in a surgical setting. Trends in biotechnology. 2020 Jun 1;38(6):594-605. DOI: 10.1016/j.tibtech.2020.01.004 DOI: https://doi.org/10.1016/j.tibtech.2020.01.004
13. Castilho M, de Ruijter M, Beirne S, Villette CC, Ito K, Wallace GG, Malda J. Multitechnology biofabrication: a new approach for the manufacturing of functional tissue structures?. Trends in biotechnology. 2020 Dec 1;38(12):1316-28. DOI: 10.1016/j.tibtech.2020.04.014 DOI: https://doi.org/10.1016/j.tibtech.2020.04.014
14. Sekar MP, Budharaju H, Zennifer A, Sethuraman S, Vermeulen N, Sundaramurthi D, Kalaskar DM. Current standards and ethical landscape of engineered tissues—3D bioprinting perspective. Journal of tissue engineering. 2021 Jul;12:20417314211027677. https://doi.org/10.1177/20417314211027677 DOI: https://doi.org/10.1177/20417314211027677
15. Wang Z, Wang L, Li T, Liu S, Guo B, Huang W, Wu Y. 3D bioprinting in cardiac tissue engineering. Theranostics. 2021 Jul 6;11(16):7948. doi: 10.7150/thno.61621 DOI: https://doi.org/10.7150/thno.61621
Published
Issue
Section
License
Copyright (c) 2023 Chandan Das, Renuka Jyothi S, Rohini (Author)
This work is licensed under a Creative Commons Attribution 4.0 International License.
The article is distributed under the Creative Commons Attribution 4.0 License. Unless otherwise stated, associated published material is distributed under the same licence.
