Current Approaches and Clinical Implications of Epigenetic Modifications in Cancer Therapy
DOI:
https://doi.org/10.56294/mw2024535Keywords:
Epigenetics, Cancer Therapy, DNA Methylation, Histone Modifications, Personalized TreatmentAbstract
Epigenetic changes are very important for the growth and spread of cancer because they control gene expression without changing the DNA sequence. Some of these changes, like DNA methylation, histone modifications, and non-coding RNA control, can turn on oncogenes, turn off tumor suppressor genes, and make cancer cells more aggressive. Because epigenetic changes can be undone, they are considered potential therapeutic targets for treating cancer. This essay talks about the latest methods to epigenetic medicines and what they mean for cancer care. The main goal of epigenetic treatments is to undo the abnormal epigenetic changes that cause cancer to spread. Some of the epigenetic drugs that have been studied the most are DNA methyltransferase inhibitors (like azacytidine) and histone deacetylase inhibitors (like vorinostat). Several of these drugs are already in use or are going through clinical studies. Besides that, going after non-coding RNAs like microRNAs and long non-coding RNAs has become an interesting way to change gene expression in cancer cells. Using epigenetic medicines along with common treatments like chemotherapy, immunotherapy, and targeted therapy has been shown to have better healing benefits, sometimes leading to better patient results. Epigenetic changes have a huge range of clinical effects. Epigenetic analysis of cancers can give useful signs for figuring out prognosis and treatment reaction, which makes it possible to create individual treatment plans. Also, epigenetic treatments might be able to beat drug resistance by going after the epigenetic processes that make traditional medicines less effective. However, there are problems with using epigenetic treatments in the field, such as making sure the drugs are safe, making sure they are bioavailable, and finding good ways to give the drugs.
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