Comparing Clinical Outcomes and Treatment Efficiency of 3D Conformal and Intensity Modulated Radiotherapy
DOI:
https://doi.org/10.56294/mw2024537Keywords:
3D Conformal Radiotherapy, Intensity Modulated Radiotherapy, Clinical Outcome, Treatment EfficiencyAbstract
Recently, a lot of progress has been made in using radiation therapy to treat cancer. The two most common methods are 3D Conformal Radiotherapy (3D-CRT) and Intensity Modulated Radiotherapy (IMRT). Both ways try to give tumors the exact amount of radiation they need while causing as little damage as possible to good cells around them. In this study, the clinical results and treatment effectiveness of 3D-CRT and IMRT are compared in cancer patients with different types of radiation therapy. A historical cohort study included 120 patients from different hospitals. They were split into two groups, with one group getting 3D-CRT and the other IMRT. The main goals of the study were to compare the two groups in terms of tumor control rates, side effects from treatment, and overall survival (OS). The effectiveness of the treatment was also judged by looking at the total time needed for planning and carrying out the treatment, as well as the radiation doses given to both the tumor and healthy cells. Overall, our results showed that IMRT had better tumor control rates than 3D-CRT, with more cases of local control and fewer cases of cancer coming back at treatment sites. When compared to 3D-CRT, the IMRT group had a significantly lower rate of acute radiation-induced effects, such as skin discomfort and stomach problems. Because it can send out very directed radiation beams, IMRT was also linked to less damage to good organs around the tumor, like the spinal cord and lungs. IMRT, on the other hand, needs more complicated treatment planning and takes longer to give than 3D-CRT, which can make prices and resource use go up. Even so, IMRT's higher level of accuracy made it a clear winner when it came to controlling tumors and improving patients' quality of life.
References
Toohey, K.; Hunter, M.; McKinnon, K.; Casey, T.; Turner, M.; Taylor, S.; Paterson, C. A systematic review of multimodal prehabilitation in breast cancer. Breast Cancer Res. Treat. 2023, 197, 1–37. DOI: https://doi.org/10.1007/s10549-022-06759-1
Halyard, M.Y.; Brown, L.C.; Mutter, R.W. Benefits, risks, and safety of external beam radiation therapy for breast cancer. Int. J. Women’s Health 2015, 7, 449–458. DOI: https://doi.org/10.2147/IJWH.S55552
Veronesi, U.; Cascinelli, N.; Mariani, L.; Greco, M.; Saccozzi, R.; Luini, A.; Aguilar, M.; Marubini, E. Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer. N. Engl. J. Med. 2002, 347, 1227–1232. DOI: https://doi.org/10.1056/NEJMoa020989
Darby, S.C.; Ewertz, M.; McGale, P.; Bennet, A.M.; Blom-Goldman, U.; Brønnum, D.; Correa, C.; Cutter, D.; Gagliardi, G.; Gigante, B.; et al. Risk of ischemic heart disease in women after radiotherapy for breast cancer. N. Engl. J. Med. 2013, 368, 987–998. DOI: https://doi.org/10.1056/NEJMoa1209825
Halperin, E.C.; Brady, L.W.; Perez, C.A.; Wazer, D.E. Perez & Brady’s Principles and Practice of Radiation Oncology; Lippincott Williams & Wilkins: Philadelphia, PA, USA, 2013.
Conway, J.L.; Conroy, L.; Harper, L.; Scheifele, M.; Li, H.; Smith, W.L.; Graham, T.; Phan, T.; Olivotto, I.A. Deep inspiration breath-hold produces a clinically meaningful reduction in ipsilateral lung dose during locoregional radiation therapy for some women with right-sided breast cancer. Pract. Radiat. Oncol. 2017, 7, 147–153. DOI: https://doi.org/10.1016/j.prro.2016.10.011
Arabaci, A.; Solak, N. Investigation of Thermal Decomposition Behavior of Cerium (III) Acetate Hydrate. Gazi Univ. J. Sci. 2012, 25, 777–782.
Eber, J.; Blondet, C.; Schmitt, M.; Cox, D.G.; Vit, C.; Le Fèvre, C.; Antoni, D.; Hubele, F.; Noel, G. Efficacity of Deep Inspiration Breath Hold and Intensity-Modulated Radiotherapy in Preventing Perfusion Defect for Left Sided Breast Cancer (EDIPE): A Prospective Cohort Study Protocol. Cancers 2023, 15, 2467. DOI: https://doi.org/10.3390/cancers15092467
Nielsen, M.H.; Berg, M.; Pedersen, A.N.; Andersen, K.; Glavicic, V.; Jakobsen, E.H.; Jensen, I.; Josipovic, M.; Lorenzen, E.L.; Nielsen, H.M.; et al. Delineation of target volumes and organs at risk in adjuvant radiotherapy of early breast cancer: National guidelines and contouring atlas by the Danish Breast Cancer Cooperative Group. Acta Oncol. 2013, 52, 703–710. DOI: https://doi.org/10.3109/0284186X.2013.765064
Hoyer, M.; Thor, M.; Thornqvist, S.; Sondergaard, J.; Lassen-Ramshad, Y.; Muren, L.P. Advances in radiotherapy: From 2D to 4D. Cancer Imaging 2011, 11, S145–S152. DOI: https://doi.org/10.1102/1470-7330.2011.9036
Cante, D.; Franco, P.; Sciacero, P.; Girelli, G.; Pasquino, M.; Borca, V.C.; Tofani, S.; La Porta, M.R.; Ricardi, U. Hypofractionated whole-breast radiotherapy and concomitant boost after breast conservation in elderly patients. Tumori J. 2016, 102, 196–202. DOI: https://doi.org/10.5301/tj.5000402
Hodapp, N. The ICRU Report 83: Prescribing, recording and reporting photon-beam intensity-modulated radiation therapy (IMRT). Strahlenther. Onkol. 2012, 188, 97–99. DOI: https://doi.org/10.1007/s00066-011-0015-x
Roach, M., III; Nam, J.; Gagliardi, G.; El Naqa, I.; Deasy, J.O.; Marks, L.B. radiation dose–volume effects and the penile bulb. Int. J. Radiat. Oncol. 2010, 76, S130–S134. DOI: https://doi.org/10.1016/j.ijrobp.2009.04.094
Emami, B. Tolerance of normal tissue to therapeutic radiation. Rep. Radiother. Oncol. 2013, 1, 123–127.
Pembroke, C.; Hudson, E.; Hanna, L. Management of cancer of the body of. Pract. Clin. Oncol. 2015, 360. DOI: https://doi.org/10.1017/CBO9781107280250.028
Hayden, A.J.; Rains, M.; Tiver, K. Deep inspiration breath hold technique reduces heart dose from radiotherapy for left-sided breast cancer. J. Med. Imaging Radiat. Oncol. 2012, 56, 464–472. DOI: https://doi.org/10.1111/j.1754-9485.2012.02405.x
Zarenezhad, E.; Kanaan, M.H.G.; Abdollah, S.S.; Vakil, M.K.; Marzi, M.; Mazarzaei, A.; Ghasemian, A. Metallic Nanoparticles: Their Potential Role in Breast Cancer Immunotherapy via Trained Immunity Provocation. Biomedicines 2023, 11, 1245. DOI: https://doi.org/10.3390/biomedicines11051245
Lu, Y.; Yang, D.; Zhang, X.; Teng, Y.; Yuan, W.; Zhang, Y.; He, R.; Tang, F.; Pang, J.; Han, B.; et al. Comparison of deep inspiration breath hold versus free breathing in radiotherapy for left sided breast cancer. Front. Oncol. 2022, 12, 845037. DOI: https://doi.org/10.3389/fonc.2022.845037
Beaton, L.; Bergman, A.; Nichol, A.; Aparicio, M.; Wong, G.; Gondara, L.; Speers, C.; Weir, L.; Davis, M.; Tyldesley, S. Cardiac death after breast radiotherapy and the QUANTEC cardiac guidelines. Clin. Transl. Radiat. Oncol. 2019, 19, 39–45. DOI: https://doi.org/10.1016/j.ctro.2019.08.001
Yan, Y.; Lu, Z.; Liu, Z.; Luo, W.; Shao, S.; Tan, L.; Ma, X.; Liu, J.; Drokow, E.K.; Ren, J. Dosimetric comparison between three- and four-dimensional computerised tomography radiotherapy for breast cancer. Oncol. Lett. 2019, 18, 1800–1814. DOI: https://doi.org/10.3892/ol.2019.10467
Petit, C.; Escande, A.; Sarrade, T.; Vaugier, L.; Kirova, Y.; Tallet, A. Radiation therapy in the thoracic region: Radio-induced cardiovascular disease, cardiac delineation and sparing, cardiac dose constraints, and cardiac implantable electronic devices. Cancer/Radiothérapie 2023, 27, 588–598. DOI: https://doi.org/10.1016/j.canrad.2023.06.027
Das Majumdar, S.K.; Amritt, A.; Dhar, S.S.; Barik, S.; Beura, S.S.; Mishra, T.; Muduly, D.K.; Dash, A.; Parida, D.K. A Dosimetric study comparing 3D-CRT vs. IMRT vs. VMAT in left-sided breast cancer patients after mastectomy at a tertiary care centre in eastern india. Cureus 2022, 14, e23568. DOI: https://doi.org/10.7759/cureus.23568
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Copyright (c) 2024 Neha Rana, Manashree Mane, Bodireddy Vamalatha, B Reddy, Naresh Kaushik, Anoop Dev, Adya Kinkar Panda (Author)
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