Echoes in the Genome: Smoking’s Epigenetic Fingerprints and Bidirectional Neurobiological Pathways in Addiction and Disease
DOI:
https://doi.org/10.56294/mw2024.585Keywords:
Smoking, Epigenetics, DNA Methylation, Neurobiology, Addiction, Bidirectional Pathways, Oxidative Stress, Inflammation, Systems Biology, Personalized MedicineAbstract
Smoking remains a global health crisis, contributing to addiction and diverse diseases through complex biological mechanisms. This study explores the hypothesis that smoking induces epigenetic modifications and alters bidirectional neurobiological pathways, perpetuating addiction and disease progression. Leveraging a dataset of 55,692 individuals with 27 health metrics, we analyze associations between smoking status and physiological markers (e.g., lipid profiles, blood pressure, liver enzymes) to infer potential epigenetic and neurobiological mediators. Preliminary data reveal significant correlations between smoking and elevated triglycerides, LDL cholesterol, and liver function markers, suggesting systemic inflammation and oxidative stress as plausible intermediaries. We propose a methodology integrating bioinformatics and systems biology to map smoking-associated phenotypic changes to epigenetic loci (e.g., DNA methylation) and neural circuits (e.g., dopaminergic pathways). This work aims to bridge clinical observations with molecular mechanisms, offering insights into personalized interventions targeting smoking’s epigenetic "fingerprints" and their neurobiological consequences.
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